Research Paper Volume 13, Issue 1 pp 735—749

TRIM3 attenuates apoptosis in Parkinson's disease via activating PI3K/AKT signal pathway

TRIM3 inhibited apoptosis of brain tissue cells in PD mice. (A and B) TRIM3 mRNA and protein expression in the midbrain of mice in MPTP + oeTRIM3 group was significantly elevated when compared with MPTP + oeNC group. (C) Markedly lower Tunel positive cell number was found in the midbrain of mice in MPTP + oeTRIM3 group relative to MPTP + oeNC group. (D) Prominently higher GSH and SOD levels were observed in the midbrain of mice in MPTP + oeTRIM3 group when compared with MPTP + oeNC group. (E) Compared with MPTP + oeNC group, more TH positive expression dopaminergic neurons were observed in MPTP + oeTRIM3 group. ** P

Figure 2. TRIM3 inhibited apoptosis of brain tissue cells in PD mice. (A and B) TRIM3 mRNA and protein expression in the midbrain of mice in MPTP + oeTRIM3 group was significantly elevated when compared with MPTP + oeNC group. (C) Markedly lower Tunel positive cell number was found in the midbrain of mice in MPTP + oeTRIM3 group relative to MPTP + oeNC group. (D) Prominently higher GSH and SOD levels were observed in the midbrain of mice in MPTP + oeTRIM3 group when compared with MPTP + oeNC group. (E) Compared with MPTP + oeNC group, more TH positive expression dopaminergic neurons were observed in MPTP + oeTRIM3 group. ** P < 0.01.