Research Paper Volume 13, Issue 1 pp 735—749

TRIM3 attenuates apoptosis in Parkinson's disease via activating PI3K/AKT signal pathway

TRIM3 attenuated apoptosis in PD cell model via activating PI3K/AKT signal pathway. (A) TRIM3 promoted proliferation of SH-SY5Y cells induced by MPP+ solution. (B) TRIM3 attenuated apoptosis of SH-SY5Y cells induced by MPP+ solution. (C) TRIM3 elevated Bcl-2 protein expression and reduced Bax, Cleaved-caspase 3 and Cleaved-caspase 9 proteins expression in SH-SY5Y cells induced by MPP+ solution. (D) TRIM3 increased the ratio of p-PI3K/PI3K and p-AKT/AKT in SH-SY5Y cells induced by MPP+ solution. * P P

Figure 4. TRIM3 attenuated apoptosis in PD cell model via activating PI3K/AKT signal pathway. (A) TRIM3 promoted proliferation of SH-SY5Y cells induced by MPP+ solution. (B) TRIM3 attenuated apoptosis of SH-SY5Y cells induced by MPP+ solution. (C) TRIM3 elevated Bcl-2 protein expression and reduced Bax, Cleaved-caspase 3 and Cleaved-caspase 9 proteins expression in SH-SY5Y cells induced by MPP+ solution. (D) TRIM3 increased the ratio of p-PI3K/PI3K and p-AKT/AKT in SH-SY5Y cells induced by MPP+ solution. * P < 0.05 and ** P < 0.01.