Research Paper Volume 13, Issue 1 pp 735—749

TRIM3 attenuates apoptosis in Parkinson's disease via activating PI3K/AKT signal pathway

PI3K inhibitor treatment reversed the inhibitory effect of TRIM3 overexpression on PD cells apoptosis. (A) PI3K inhibitor treatment reversed the promoting effect of TRIM3 overexpression on PD cells proliferation. (B) PI3K inhibitor treatment reversed the promoting effect of TRIM3 overexpression on GSH and SOD secretion in PD cells. (C) PI3K inhibitor treatment reversed the inhibitory effect of TRIM3 overexpression on ROS level in PD cells. (D) PI3K inhibitor treatment reversed the inhibitory effect of TRIM3 overexpression on the MMP of PD cells. (E) PI3K inhibitor treatment reversed the inhibitory effect of TRIM3 overexpression on PD cells apoptosis. (F) PI3K inhibitor treatment reversed the effected of TRIM3 overexpression on apoptosis-related proteins expression in PD cells. * P P

Figure 5. PI3K inhibitor treatment reversed the inhibitory effect of TRIM3 overexpression on PD cells apoptosis. (A) PI3K inhibitor treatment reversed the promoting effect of TRIM3 overexpression on PD cells proliferation. (B) PI3K inhibitor treatment reversed the promoting effect of TRIM3 overexpression on GSH and SOD secretion in PD cells. (C) PI3K inhibitor treatment reversed the inhibitory effect of TRIM3 overexpression on ROS level in PD cells. (D) PI3K inhibitor treatment reversed the inhibitory effect of TRIM3 overexpression on the MMP of PD cells. (E) PI3K inhibitor treatment reversed the inhibitory effect of TRIM3 overexpression on PD cells apoptosis. (F) PI3K inhibitor treatment reversed the effected of TRIM3 overexpression on apoptosis-related proteins expression in PD cells. * P < 0.05 and ** P < 0.01.