Research Paper Volume 13, Issue 1 pp 750—768

KRAS mutations are negatively correlated with immunity in colon cancer

Survival analysis of KRAS mutations in colon cancer. (A–D) The survival rate of patients with different base-pairs in rs112445441, rs121913527, rs121913529, and rs121913530. (E, F) Comparison of the survival rates between KRAS-mutated and wild-type patients from the ICGC and TCGA databases. The difference in survival rate was statistically significant in ICGC (P=0.04), but not in TCGA (P=0.8469). In TCGA analysis, there were 171 and 225 patients with and without KRAS mutations, respectively. In ICGC analysis, there were 112 and 196 patients with and without KRAS mutations, respectively.

Figure 2. Survival analysis of KRAS mutations in colon cancer. (AD) The survival rate of patients with different base-pairs in rs112445441, rs121913527, rs121913529, and rs121913530. (E, F) Comparison of the survival rates between KRAS-mutated and wild-type patients from the ICGC and TCGA databases. The difference in survival rate was statistically significant in ICGC (P=0.04), but not in TCGA (P=0.8469). In TCGA analysis, there were 171 and 225 patients with and without KRAS mutations, respectively. In ICGC analysis, there were 112 and 196 patients with and without KRAS mutations, respectively.