Research Paper Volume 13, Issue 1 pp 750—768

KRAS mutations are negatively correlated with immunity in colon cancer

ssGESA and ESTIMATE analysis of the relationship between KRAS mutations and immune activities. (A) In ssGSEA, 30 immune-related pathways were incorporated to estimate the immune capacity of individual colon cancer samples. These gene sets were composed of immune cells and processes. The tumor purity, immune score, and stromal score are also shown in the heatmap. (B–D) Using the Mann-Whitney test, we found that the KRAS-mutated group was of lower immune and stromal score while its tumor purity was higher than the wild-type group.

Figure 4. ssGESA and ESTIMATE analysis of the relationship between KRAS mutations and immune activities. (A) In ssGSEA, 30 immune-related pathways were incorporated to estimate the immune capacity of individual colon cancer samples. These gene sets were composed of immune cells and processes. The tumor purity, immune score, and stromal score are also shown in the heatmap. (BD) Using the Mann-Whitney test, we found that the KRAS-mutated group was of lower immune and stromal score while its tumor purity was higher than the wild-type group.