Research Paper Volume 13, Issue 1 pp 831—845

Atorvastatin improves motor function, anxiety and depression by NOX2-mediated autophagy and oxidative stress in MPTP-lesioned mice

Effects of atorvastatin on behavior in PD mice. (A) The detection of depression using the tail suspension test. (B) The detection of anxiety using the elevated plus maze test. The results were expressed as the percentage of time spent in open arms and the whole experiment time ratio. (C) The detection of muscle capacity using the rotarod test. The results were expressed as the fall down time(s) of the whole experiment time. The results compared to the control group are expressed as **p ***p #p

Figure 1. Effects of atorvastatin on behavior in PD mice. (A) The detection of depression using the tail suspension test. (B) The detection of anxiety using the elevated plus maze test. The results were expressed as the percentage of time spent in open arms and the whole experiment time ratio. (C) The detection of muscle capacity using the rotarod test. The results were expressed as the fall down time(s) of the whole experiment time. The results compared to the control group are expressed as **p < 0.01, ***p < 0.001. The results compared to the MPTP group are expressed as #p < 0.05.