Research Paper Volume 13, Issue 1 pp 831—845

Atorvastatin improves motor function, anxiety and depression by NOX2-mediated autophagy and oxidative stress in MPTP-lesioned mice

Atorvastatin reduces the number of dead MPTP-induced nigral neurons in the autophagic flux marker PD mouse. Immunohistochemistry of tyrosine hydroxylase in the substantia nigra neurons of an autophagic flux marker mouse model (A–D). Immunohistochemistry of α-Syn Ser129 substantia nigra neurons in an autophagic flux marker mouse model (E–H). Bar = 100 μm. Quantitative analysis of TH positive neurons and α-syn ser129 positive neurons (I, J). The results are expressed as ***p #p

Figure 2. Atorvastatin reduces the number of dead MPTP-induced nigral neurons in the autophagic flux marker PD mouse. Immunohistochemistry of tyrosine hydroxylase in the substantia nigra neurons of an autophagic flux marker mouse model (AD). Immunohistochemistry of α-Syn Ser129 substantia nigra neurons in an autophagic flux marker mouse model (EH). Bar = 100 μm. Quantitative analysis of TH positive neurons and α-syn ser129 positive neurons (I, J). The results are expressed as ***p < 0.001 compared to atorvastatin/MPTP (-/-). The results were expressed as #p < 0.05 compared to atorvastatin/MPTP (-/+).