Atorvastatin improves motor function, anxiety and depression by NOX2-mediated autophagy and oxidative stress in MPTP-lesioned mice

Junqiang Yan; Jiarui Huang; Anran Liu; Jiannan Wu; Hua Fan; Mengmeng Shen; Xiaoyi Lai; Hongxia Ma; Wenjie Sun; Jianxue Yang; Yunqi Xu

doi:doi:10.18632/aging.202189

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Research Paper Volume 13, Issue 1 pp 831—845

Atorvastatin improves motor function, anxiety and depression by NOX2-mediated autophagy and oxidative stress in MPTP-lesioned mice

Figure 9. Atorvastatin rescues the expression of antioxidant stress Nrf2, HO-1 and NQO-1 (A–D) by inhibiting NOX2 in MPTP mice. The results are expressed as ^*p < 0.05 or ^**p < 0.01 or ^***p < 0.001; NS indicates no significance compared to MPTP/atorvastatin/NOX2-shRNA (-/-/-). The results are expressed as ^#p < 0.05 or ^##p < 0.05 compared to MPTP/atorvastatin/NOX2-shRNA (+/-/-).