Research Paper Volume 13, Issue 1 pp 865—876

Propofol reduces renal ischemia/reperfusion-induced acute lung injury by stimulating sirtuin 1 and inhibiting pyroptosis

Propofol inhibits the rI/R-induced downregulation of SIRT1 in the lungs of rats. Rats were subjected to rI/R, with or without propofol (5 or 10 mg/kg) treatment for 24 h. (A) Immunofluorescence analysis was used to measure the fluorescence intensity of SIRT1. (B) Real-time PCR was used to measure the mRNA expression of SIRT1 (*P #P

Figure 6. Propofol inhibits the rI/R-induced downregulation of SIRT1 in the lungs of rats. Rats were subjected to rI/R, with or without propofol (5 or 10 mg/kg) treatment for 24 h. (A) Immunofluorescence analysis was used to measure the fluorescence intensity of SIRT1. (B) Real-time PCR was used to measure the mRNA expression of SIRT1 (*P < 0.05 vs. sham; #P < 0.05 vs. rI/R).