Research Paper Volume 13, Issue 1 pp 910—932

Tanshinone IIA attenuates atherosclerosis via inhibiting NLRP3 inflammasome activation

Effects of Tan IIA on HCh diet-induced AS lesion formation, serum lipid levels and cytokine productions in ApoE-/- mice. (A) Molecular structure of Tanshinone IIA. (B) AS lesions stained by Oil Red O in the aorta of ApoE-deficient mice fed on the different diets (regular diet, HCh diet and HCh diet plus Tan IIA (20 mg/kg/day)). (C) Percentage of the lesion area of the aorta was calculated as the ratio of the lesion area to the total area. (D) Histological images of frozen section of the lesions stained with Oil Red O and Haematoxylin/eosin (HE). (E) Relative lesion area of the section of AS in the aorta. Average areas of AS lesions were calculated from 12 sections in ApoE-deficient mice fed on the different diets. (F–G) Levels of T-Ch and HDL-Ch in the sera of ApoE-deficient mice fed with different diets for 16 weeks.

Figure 1. Effects of Tan IIA on HCh diet-induced AS lesion formation, serum lipid levels and cytokine productions in ApoE-/- mice. (A) Molecular structure of Tanshinone IIA. (B) AS lesions stained by Oil Red O in the aorta of ApoE-deficient mice fed on the different diets (regular diet, HCh diet and HCh diet plus Tan IIA (20 mg/kg/day)). (C) Percentage of the lesion area of the aorta was calculated as the ratio of the lesion area to the total area. (D) Histological images of frozen section of the lesions stained with Oil Red O and Haematoxylin/eosin (HE). (E) Relative lesion area of the section of AS in the aorta. Average areas of AS lesions were calculated from 12 sections in ApoE-deficient mice fed on the different diets. (FG) Levels of T-Ch and HDL-Ch in the sera of ApoE-deficient mice fed with different diets for 16 weeks.