Research Paper Volume 12, Issue 21 pp 22291—22312

LncRNA PVT1 accelerates malignant phenotypes of bladder cancer cells by modulating miR-194-5p/BCLAF1 axis as a ceRNA

Figure 10. The schematic diagram of the oncogenic role of PVT1 in BC cells. PVT1 functions as a miRNA sponge to positively regulate the expression of BCLAF1 through sponging miR-194-5p and subsequently promotes malignant phenotypes of BC cells, and thus it plays an oncogenic role in BC pathogenesis.