Research Paper Volume 12, Issue 24 pp 25981—25999

Profilin 2 promotes growth, metastasis, and angiogenesis of small cell lung cancer through cancer-derived exosomes

Figure 2. PFN2 overexpression promotes the proliferation, migration, and invasion of SCLC cells. PFN2 expression is significantly increased in H446 cells with PFN2 overexpression (P=0.02) (A). PFN2 overexpression shows significantly improved proliferation (P=0.6133, 0.1860, 0.0956, and 0.0278 at 6 h, 12 h, 18 h, and 24 h, respectively) (B), migration (P=0.0001) (C), and invasion (P=0.018) (D) of H446 cells. PFN2 expression is significantly decreased in H446 cells with PFN2 knockdown (P=0.03) (E). PFN2 knockdown shows markedly inhibited proliferation (P=0.3740, 0.7718, 0.0114, and 0.0027 at 6 h, 12 h, 18 h, and 24 h, respectively) (F), migration (P=0.002) (G), and invasion (P=0.0301) (H) of H446 cells (n=3). Overexpression control (OC), knockdown control (KC), and wild type (WT) of H446 cells show similar proliferation (P=0.1208, 0.2105, 0.7942, and 0.03275 at 6 h, 12 h, 18 h, and 24 h respectively) (I), migration (P=0.2721) (J), and invasion (P=0.3603) (K).