Research Paper Volume 13, Issue 1 pp 1071—1095

Integrated proteome and phosphoproteome analyses of peripheral blood mononuclear cells in primary Sjögren syndrome patients

(A) The schematic flow to study the proteome and phosphoproteome of peripheral blood mononuclear cells (PBMCs) in primary Sjögren syndrome (pSS) patients. (B) Histogram of quantity distribution of differentially expressed proteins (DEPs). (C) Gene Ontology (GO) classifications of the DEPs of PBMCs in pSS patients based on biological process, cellular component and molecular function. (D) Histogram of quantity distribution of differentially expressed phosphorylated proteins (DPPs). IMAC: immobilized metal affinity chromatography. LC-MS: liquid chromatography–mass spectrometry.

Figure 1. (A) The schematic flow to study the proteome and phosphoproteome of peripheral blood mononuclear cells (PBMCs) in primary Sjögren syndrome (pSS) patients. (B) Histogram of quantity distribution of differentially expressed proteins (DEPs). (C) Gene Ontology (GO) classifications of the DEPs of PBMCs in pSS patients based on biological process, cellular component and molecular function. (D) Histogram of quantity distribution of differentially expressed phosphorylated proteins (DPPs). IMAC: immobilized metal affinity chromatography. LC-MS: liquid chromatography–mass spectrometry.