Research Paper Volume 13, Issue 1 pp 1071—1095

Integrated proteome and phosphoproteome analyses of peripheral blood mononuclear cells in primary Sjögren syndrome patients

Protein-protein interaction (PPI) network analyses of differentially expressed proteins (DEPs) were performed and 3 most significant modules were yielded by molecular complex detection (MCODE) algorithm. Red and light cyan indicate up- and down-regulated differentially expressed proteins (DEPs), respectively. (A). Module 1 (score =33.000) was constructed with 26 nodes and 325 edges. (B) Module 2 (score =17.758)) was constructed with 34 nodes and 293 edges. (C) Module 3 (score =12.261) was constructed with 24 nodes and 141 edges.

Figure 3. Protein-protein interaction (PPI) network analyses of differentially expressed proteins (DEPs) were performed and 3 most significant modules were yielded by molecular complex detection (MCODE) algorithm. Red and light cyan indicate up- and down-regulated differentially expressed proteins (DEPs), respectively. (A). Module 1 (score =33.000) was constructed with 26 nodes and 325 edges. (B) Module 2 (score =17.758)) was constructed with 34 nodes and 293 edges. (C) Module 3 (score =12.261) was constructed with 24 nodes and 141 edges.