Research Paper Volume 13, Issue 1 pp 1132—1152

Ginsenoside RG1 enhances the paracrine effects of bone marrow-derived mesenchymal stem cells on radiation induced intestinal injury

RG1-MSC-CM improves intestinal function and structure of irradiated rats. (A) Histological analysis by H&E staining. Scale bars 100 μm, magnification 10×. (B) Morphometric evaluation of epithelium thickness. Each value represents the average of 20 independent measurements per animal (5 animals per group). Value is reported as mean ± SD. **, P ##, P C) Absorption function of intestines in irradiated rats was evaluated by D-xylose absorption experiment on 1, 3, 7 days after radiation. Data represent mean ± SD, **, P ##, P D) Intestinal permeability in rats was measured by plasma level of D-lactate on 1, 3, 7 days after radiation. Data represent mean ± SD. **, P ##, P

Figure 3. RG1-MSC-CM improves intestinal function and structure of irradiated rats. (A) Histological analysis by H&E staining. Scale bars 100 μm, magnification 10×. (B) Morphometric evaluation of epithelium thickness. Each value represents the average of 20 independent measurements per animal (5 animals per group). Value is reported as mean ± SD. **, P < 0.05 versus IR + DMEM-F12, ##, P < 0.05 versus IR + MSC-CM. (C) Absorption function of intestines in irradiated rats was evaluated by D-xylose absorption experiment on 1, 3, 7 days after radiation. Data represent mean ± SD, **, P < 0.05 versus IR + DMEM-F12, ##, P < 0.05 versus IR + MSC-CM. Data represent mean ± SD. (D) Intestinal permeability in rats was measured by plasma level of D-lactate on 1, 3, 7 days after radiation. Data represent mean ± SD. **, P < 0.05 versus IR + DMEM-F12, ##, P < 0.05 versus IR + MSC-CM. All data were analyzed by t-test or one-way ANOVA except as otherwise indicated.