Research Paper Advance Articles

PTP1B inhibitor alleviates deleterious microglial activation and neuronal injury after ischemic stroke by modulating the ER stress-autophagy axis via PERK signaling in microglia

Schematic diagram of the indicated molecular mechanisms underlying the protective effects of PTP1B inhibitor treatment against cerebral ischemia/reperfusion injury. PTP1B inhibitor treatment alleviated cerebral IR-induced microglial ER stress as well as downstream autophagy, and ultimately mitigated deleterious activation of microglia. PTP1B inhibitor attenuated microglial ER stress possibly by inhibiting PERK signaling. PTP1Bsc = PTP1B inhibitor sc-222227.

Figure 8. Schematic diagram of the indicated molecular mechanisms underlying the protective effects of PTP1B inhibitor treatment against cerebral ischemia/reperfusion injury. PTP1B inhibitor treatment alleviated cerebral IR-induced microglial ER stress as well as downstream autophagy, and ultimately mitigated deleterious activation of microglia. PTP1B inhibitor attenuated microglial ER stress possibly by inhibiting PERK signaling. PTP1Bsc = PTP1B inhibitor sc-222227.