Research Paper Advance Articles

Hypoxia-inducible factor 2-alpha-dependent induction of IL-6 protects the heart from ischemia/reperfusion injury

Effect of exogenous IL-6 supplementation on myocardial infarct size and troponin I in endogenous IL-6 knockdown mice or HIF2α deficiency mice. (A) Representative image and quantitative analysis of TTC and Evans blue staining after mouse heart I/R with IL-6 supplementation in IL-6 deficiency mice. n = 8 per group. (B) The results of troponin I release subsequent to I/R. n = 5 per group. (C) Representative image and quantitative analysis of TTC and Evans blue staining after mouse heart I/R with IL-6 supplementation in HIF2α deficiency mice. n = 8 per group. (D) The results of troponin I analysis. n = 5 per group. Data represent the mean± SEM. *PP

Figure 5. Effect of exogenous IL-6 supplementation on myocardial infarct size and troponin I in endogenous IL-6 knockdown mice or HIF2α deficiency mice. (A) Representative image and quantitative analysis of TTC and Evans blue staining after mouse heart I/R with IL-6 supplementation in IL-6 deficiency mice. n = 8 per group. (B) The results of troponin I release subsequent to I/R. n = 5 per group. (C) Representative image and quantitative analysis of TTC and Evans blue staining after mouse heart I/R with IL-6 supplementation in HIF2α deficiency mice. n = 8 per group. (D) The results of troponin I analysis. n = 5 per group. Data represent the mean± SEM. *P<0.05, **P<0.01 versus the indicated group.