Research Paper Advance Articles pp 24117—24133

Dilated cardiomyopathy impairs mitochondrial biogenesis and promotes inflammation in an age- and sex-dependent manner

Figure 2. DCM-related alterations in expression of mitochondrial proteins and anti-oxidative enzymes in older patients. Western blot analysis of PGC1-α (A), TOM40 (B), TIM23 (C), Sirt3 (D), SOD2 (E) and catalase (F) expression performed with human cardiac tissue lysates from old control (non-diseased) or DCM men () and women (). Representative imaging of western blot analysis; the lanes were run in two gels. All data were normalized to the corresponding control and expressed in relative units (r.u.). Data are means ± SEM (n= 5).