Research Paper Advance Articles

ESRP1 regulates alternative splicing of CARM1 to sensitize small cell lung cancer cells to chemotherapy by inhibiting TGF-β/Smad signaling

ESRP1 inhibits the growth and chemoresistance of SCLC in vivo. (A) Tumor formation of H69AR cells stably with up-regulated ESRP1 or the vector control (n = 5 nudes for each group). (B) Growth curve of tumor volumes. (C) Tumor weight taken from nude mice. (D) Tumors formation of H69 cells stably with down-regulated ESRP1 or the vector control (n = 5 nudes for each group). (E) Growth curve of tumor volumes. (F) Tumor weight taken from nude mice. *, pp

Figure 3. ESRP1 inhibits the growth and chemoresistance of SCLC in vivo. (A) Tumor formation of H69AR cells stably with up-regulated ESRP1 or the vector control (n = 5 nudes for each group). (B) Growth curve of tumor volumes. (C) Tumor weight taken from nude mice. (D) Tumors formation of H69 cells stably with down-regulated ESRP1 or the vector control (n = 5 nudes for each group). (E) Growth curve of tumor volumes. (F) Tumor weight taken from nude mice. *, p<0.05; ***, p <0.001.