Research Paper Advance Articles pp 23525—23547

Mutation in histone deacetylase HDA-3 leads to shortened locomotor healthspan in Caenorhabditis elegans

Figure 3. HDA-3 G271E missense mutation occurs at evolutionarily conserved residue. (A) (Top) Depiction of hda-3(ix241) mutation site in HDA-3 protein. (Bottom) Alignment of amino acid sequences centered around G271E mutation site in C. elegans HDA-3, H. sapiens HDAC1, HDAC2 and HDAC3. (B) (Top) Structural modeling of C. elegans WT HDA-3 based on PDB: 4A69 from H. Sapiens HDAC3. (Bottom) Structural modeling of C. elegans HDA-3 G271E based on PDB: 4A69 from H. Sapiens HDAC3. Mutated glutamic acid residue is shown in magenta. HDAC domain is indicated in blue.