Research Paper Advance Articles pp 23525—23547

Mutation in histone deacetylase HDA-3 leads to shortened locomotor healthspan in Caenorhabditis elegans

Figure 6. Specific BATH genes on Chromosome II are downregulated from HDA-3 mutations. (A) Genomic location of strongly downregulated gene transcripts on Chromosome II in OF1263 vs. WT. (B) Locations of BATH genes on Chromosome II. (C) Fold change in BATH genes in OF1355 hda-3(ix261) worms compared to WT, as measured by qPCR. (D) Fold change in BATH genes in hda-3(ok1991) worms compared to WT, as measured by qPCR. (E) Maximum velocities of worms fed with empty vector RNAi or RNAi targeted towards bath-1, bath-21, or bath-24. N = 30–45 worms per strain for each day (10–15 worms from 3 biological replicate plates). ***p < 0.001; **p < 0.01; *p < 0.05.