Research Paper Volume 13, Issue 1 pp 163—180
Identification of a novel and potent small molecule inhibitor of SRPK1: mechanism of dual inhibition of SRPK1 for the inhibition of cancer progression
Figure 1. Surface and ligplot diagrams showing docking and binding interactions of selected compounds at the ATP site of SRPK1. (A) Compound C01, (B) Compound C02, (C) Compound C03, (D) Compound C04, (E) Compound C05, (F) Compound C06. All compounds occupied the similar space in the binding site. It is noteworthy to observe the additional unique Interactions of compound C02 with His170, Tyr227 and Lys174 amino acid residues of SRPK1.