Research Paper Volume 13, Issue 2 pp 2640—2654

MiR-16-5p suppresses myofibroblast activation in systemic sclerosis by inhibiting NOTCH signaling

GO and KEGG enrichment analysis of DEGs. DEGs in SSc patients were significantly enriched in the following categories and pathways: in the biological process category, defense response to virus, response to virus, and type I interferon; in the cellular component category, membrane, cytosol, and Golgi apparatus; in the molecular function category, protein binding, double-stranded RNA binding, and phosphatase activity.

Figure 4. GO and KEGG enrichment analysis of DEGs. DEGs in SSc patients were significantly enriched in the following categories and pathways: in the biological process category, defense response to virus, response to virus, and type I interferon; in the cellular component category, membrane, cytosol, and Golgi apparatus; in the molecular function category, protein binding, double-stranded RNA binding, and phosphatase activity.