Research Paper Volume 13, Issue 2 pp 2668—2680

Notch-1 promotes the malignant progression of osteosarcoma through the activation of cell division cycle 20

Cdc20 overexpression abrogated Notch-1 shRNA-mediated antineoplastic effects. (A) Viability was examined in cells cotransfected with Notch-1 shRNA and Cdc20 cDNA. *P # P B) Apoptosis was examined in osteosarcoma cells after Notch-1 shRNA and Cdc20 cDNA cotransfection.

Figure 5. Cdc20 overexpression abrogated Notch-1 shRNA-mediated antineoplastic effects. (A) Viability was examined in cells cotransfected with Notch-1 shRNA and Cdc20 cDNA. *P < 0.05 vs control shRNA, # P < 0.05 vs Notch-1 shRNA or Cdc20 cDNA. (B) Apoptosis was examined in osteosarcoma cells after Notch-1 shRNA and Cdc20 cDNA cotransfection.