Research Paper Volume 13, Issue 3 pp 3645—3660

Enrichment of branched chain amino acid transaminase 1 correlates with multiple biological processes and contributes to poor survival of IDH1 wild-type gliomas

BCAT1 is correlated with apoptosis, hypoxia and angiogenesis processes in gliomas. (A, B) Heatmaps showing the expression patterns of angiogenesis, apoptosis and hypoxia markers in glioma patients according to BCAT1 expression based on TCGA and CGGA datasets. (C–E) The relation between BCAT1 expression and apoptosis, hypoxia and angiogenesis markers in LGG of TCGA dataset. (F–H) The relation between BCAT1 expression and apoptosis, hypoxia and angiogenesis markers in GBM of TCGA dataset. (I–K) The relation between BCAT1 and apoptosis, hypoxia and angiogenesis markers in LGG of CGGA dataset. (L–N) The relation between BCAT1 and apoptosis, hypoxia and angiogenesis markers in GBM of CGGA dataset.

Figure 3. BCAT1 is correlated with apoptosis, hypoxia and angiogenesis processes in gliomas. (A, B) Heatmaps showing the expression patterns of angiogenesis, apoptosis and hypoxia markers in glioma patients according to BCAT1 expression based on TCGA and CGGA datasets. (CE) The relation between BCAT1 expression and apoptosis, hypoxia and angiogenesis markers in LGG of TCGA dataset. (FH) The relation between BCAT1 expression and apoptosis, hypoxia and angiogenesis markers in GBM of TCGA dataset. (IK) The relation between BCAT1 and apoptosis, hypoxia and angiogenesis markers in LGG of CGGA dataset. (LN) The relation between BCAT1 and apoptosis, hypoxia and angiogenesis markers in GBM of CGGA dataset.