Research Paper Volume 13, Issue 3 pp 3645—3660

Enrichment of branched chain amino acid transaminase 1 correlates with multiple biological processes and contributes to poor survival of IDH1 wild-type gliomas

BCAT1 is correlated with immunosuppressive status in gliomas. (A, B) The correlation between BCAT1 and immune checkpoints in the TCGA and CGGA datasets. (C–F) The correlation between BCAT1 and M2 markers in the TCGA dataset and (G–J) CGGA dataset. (K–N) The correlation between BCAT1 and Treg markers in the TCGA dataset and (O–R) CGGA dataset. (S, T) Heatmap showing the mRNA expression pattern of BCAT1 related immune cell markers in the TCGA and CGGA datasets, shown respectively for IDH1 mutant and wild-type gliomas and for glioma grades.

Figure 5. BCAT1 is correlated with immunosuppressive status in gliomas. (A, B) The correlation between BCAT1 and immune checkpoints in the TCGA and CGGA datasets. (CF) The correlation between BCAT1 and M2 markers in the TCGA dataset and (GJ) CGGA dataset. (KN) The correlation between BCAT1 and Treg markers in the TCGA dataset and (OR) CGGA dataset. (S, T) Heatmap showing the mRNA expression pattern of BCAT1 related immune cell markers in the TCGA and CGGA datasets, shown respectively for IDH1 mutant and wild-type gliomas and for glioma grades.