Research Paper Advance Articles

NFAT5 directs hyperosmotic stress-induced fibrin deposition and macrophage infiltration via PAI-1 in endothelium

High-salt induces the dysfunction of monocytes adhesion and infiltration in ECs via NFAT5. (A–D) mRNA expression of adhesive molecules (E-selectin, ICAM-1, VCAM-1, and MCP-1) in HUVECs that treated by Ad-null or Ad-NFAT5. (E–H) mRNA expression of adhesive molecules (E-selectin, ICAM-1, VCAM-1, and MCP-1) in HUVECs that transfected by Ctr siRNA or NFAT5 siRNA under high-salt condition. All data were presented as mean ± SEM, N≥3. *p

Figure 6. High-salt induces the dysfunction of monocytes adhesion and infiltration in ECs via NFAT5. (AD) mRNA expression of adhesive molecules (E-selectin, ICAM-1, VCAM-1, and MCP-1) in HUVECs that treated by Ad-null or Ad-NFAT5. (EH) mRNA expression of adhesive molecules (E-selectin, ICAM-1, VCAM-1, and MCP-1) in HUVECs that transfected by Ctr siRNA or NFAT5 siRNA under high-salt condition. All data were presented as mean ± SEM, N≥3. *p < 0.05 versus control group.