Research Paper Volume 13, Issue 3 pp 3661—3679

NFAT5 directs hyperosmotic stress-induced fibrin deposition and macrophage infiltration via PAI-1 in endothelium

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Figure 6. High-salt induces the dysfunction of monocytes adhesion and infiltration in ECs via NFAT5. (AD) mRNA expression of adhesive molecules (E-selectin, ICAM-1, VCAM-1, and MCP-1) in HUVECs that treated by Ad-null or Ad-NFAT5. (EH) mRNA expression of adhesive molecules (E-selectin, ICAM-1, VCAM-1, and MCP-1) in HUVECs that transfected by Ctr siRNA or NFAT5 siRNA under high-salt condition. All data were presented as mean ± SEM, N≥3. *p < 0.05 versus control group.