Research Paper Volume 13, Issue 3 pp 3680—3698

Polyglutamine-expanded ataxin3 alter specific gene expressions through changing DNA methylation status in SCA3/MJD

SCA3/MJD mice fail in the accelerated rotarod test. All animals managed to stay on a rod rotating at constant speed (5rpm) for about 5 min. When the rotation was accelerated to 10 rpm and 20 rpm, latency to fall from the test apparatus was significantly reduced in SCA3/MJD mice (p

Figure 1. SCA3/MJD mice fail in the accelerated rotarod test. All animals managed to stay on a rod rotating at constant speed (5rpm) for about 5 min. When the rotation was accelerated to 10 rpm and 20 rpm, latency to fall from the test apparatus was significantly reduced in SCA3/MJD mice (p<0.05). And the extent of reduction is depended on the rotating speed. When the speed reached 20 rpm, the latency to fall in SCA3/MJD mice were about 1min.