Research Paper Advance Articles

Polyglutamine-expanded ataxin3 alter specific gene expressions through changing DNA methylation status in SCA3/MJD

Dynamic DNA methylation and gene expression change of En1, Nkx2-1, and Otx1. (A, B) the average DNA methylation levels and transcriptional levels in 12-week-old mice. DNA methylation levels of sequence En1

Figure 5. Dynamic DNA methylation and gene expression change of En1, Nkx2-1, and Otx1. (A, B) the average DNA methylation levels and transcriptional levels in 12-week-old mice. DNA methylation levels of sequence En1_2, Nkx2-1_2 and Otx1were significantly different between the two groups (p<0.05). In 12-week-old mice, expression of En1, Nkx2-1 and Otx1 were significantly different in the two groups (p<0.05). (C, D) the average DNA methylation levels and transcriptional levels in 19-month-old mice. No significant difference was observed for DNA methylation levels in sequences in En1, Nkx2-1 and Otx1. Expression of Nkx2-1 and Otx1 were still significantly different in the two groups (p<0.05).