Research Paper Volume 13, Issue 3 pp 3742—3762

Key microRNAs and hub genes associated with poor prognosis in lung adenocarcinoma

Correlation analysis of upregulated hub genes (SPP1, COL3A1, and COL1A1) and downregulated hub genes (PECAM1, VWF, CDH5, and TEK) in LUAD. (A) SPP1 and COL1A1, (B) SPP1 and COL3A1, (C) COL1A1 and COL3A1, (D) PECAM1 and VWF, (E) PECAM1 and CDH5, (F) PECAM1 and TEK, (G) VWF and CDH5, (H) VWF and TEK, and (I) CDH5 and TEK. TPM, transcript per million. The x-axis represents the TPM of the hub gene MYC (log2). The expression levels of upregulated hub genes (SPP1, COL3A1, and COL1A1) were positively correlated with each other. The expression levels of downregulated hub genes (PECAM1, VWF, CDH5, and TEK) were positively correlated with each other.

Figure 9. Correlation analysis of upregulated hub genes (SPP1, COL3A1, and COL1A1) and downregulated hub genes (PECAM1, VWF, CDH5, and TEK) in LUAD. (A) SPP1 and COL1A1, (B) SPP1 and COL3A1, (C) COL1A1 and COL3A1, (D) PECAM1 and VWF, (E) PECAM1 and CDH5, (F) PECAM1 and TEK, (G) VWF and CDH5, (H) VWF and TEK, and (I) CDH5 and TEK. TPM, transcript per million. The x-axis represents the TPM of the hub gene MYC (log2). The expression levels of upregulated hub genes (SPP1, COL3A1, and COL1A1) were positively correlated with each other. The expression levels of downregulated hub genes (PECAM1, VWF, CDH5, and TEK) were positively correlated with each other.