Research Paper Volume 13, Issue 3 pp 3819—3842

Four hub genes regulate tumor infiltration by immune cells, antitumor immunity in the tumor microenvironment, and survival outcomes in lung squamous cell carcinoma patients

Identification and functional annotation of the hub genes in the brown module. (A) Scatter plot of the gene significance (GS) versus the module membership (MM) of the 30 hub genes in the brown module. (B) Protein-protein interaction (PPI) network of the 30 hub genes in the brown module. (C) Coexpression network analysis including visualization of the module membership (nodes) and the gene-gene connections (edges) of the top 30 hub genes in the brown module using the Cytoscape version 3.4.0 software (D) Functional enrichment analysis results show the enriched GO terms and KEGG pathways related to the DEGs in the brown module.

Figure 6. Identification and functional annotation of the hub genes in the brown module. (A) Scatter plot of the gene significance (GS) versus the module membership (MM) of the 30 hub genes in the brown module. (B) Protein-protein interaction (PPI) network of the 30 hub genes in the brown module. (C) Coexpression network analysis including visualization of the module membership (nodes) and the gene-gene connections (edges) of the top 30 hub genes in the brown module using the Cytoscape version 3.4.0 software (D) Functional enrichment analysis results show the enriched GO terms and KEGG pathways related to the DEGs in the brown module.