Figure 4. Co-methylation analysis and functional annotation of cg22626579. (A) Patterns of co-methylation at the cytosine-phosphate-guanine dinucleotide (CpG) sites surrounding cg22626579. (B) Monocyte-specific regional association results along with position of nearby CpG island (dark violet), CpG shore (yellow), CpG shelf (indigo) and CpG open sea (green yellow). cg22626579 (highlighted in shaded box) is located in CpG island. (C) Functional annotation of cg22626579. DNase hypersensitive sites derived by DNase-seq (DNase Track) and histone marks surrounding cg22626579 (H3K4me1, H3K4me3, H3K9ac and H3K27ac Tracks) in monocyte are shown. DNase hypersensitivity, H3K4me1, H3K4me3, H3K9ac and H3K27ac histone marks are associated with active regulatory elements.