Research Paper Advance Articles

Cell lineage-specific methylome and genome alterations in gout

Potential mechanisms linking surviving methylation sites with gouty inflammation. cg22626579 hypomethylation in gout increases PRKCZ, cg10314750 hypomethylation in gout increases CIDEC, cg03795507 hypomethylation in gout increases VDAC1, hypomethylated cg10257063 in gout increases CPT1A, cg16975613 hypermethylation in gout decreases BIRC2, cg16630982 and cg12182452 hypomethylation in gout increases BRCA1, cg17151991 hypomethylation in gout decreases STK11 and hypermethylated cg26375855 in gout increases NLRP12. All these culminate in increased interleukin-1β (IL-1β) production, promoting gouty inflammation.

Figure 5. Potential mechanisms linking surviving methylation sites with gouty inflammation. cg22626579 hypomethylation in gout increases PRKCZ, cg10314750 hypomethylation in gout increases CIDEC, cg03795507 hypomethylation in gout increases VDAC1, hypomethylated cg10257063 in gout increases CPT1A, cg16975613 hypermethylation in gout decreases BIRC2, cg16630982 and cg12182452 hypomethylation in gout increases BRCA1, cg17151991 hypomethylation in gout decreases STK11 and hypermethylated cg26375855 in gout increases NLRP12. All these culminate in increased interleukin-1β (IL-1β) production, promoting gouty inflammation.