Research Paper Volume 13, Issue 1 pp 1383—1409

The therapeutic significance of the novel photodynamic material TPE-IQ-2O in tumors

TPE-IQ-2O PDT combined with a PDL1 ICI can effectively inhibit tumor growth. (A) Schematic diagram of the establishment of a relatively ICI-insensitive animal model. (B, C) The tumors in the LLC or MC38 tumor-bearing mice of the control group (n=5), TPE-IQ-2O PDT group (n=5), BMS202 group (n=5) and combined treatment (PDT combined with BMS202) group (n=5). (D, E) Tumor growth curves for LLC or MC38 tumor-bearing mice, *p

Figure 6. TPE-IQ-2O PDT combined with a PDL1 ICI can effectively inhibit tumor growth. (A) Schematic diagram of the establishment of a relatively ICI-insensitive animal model. (B, C) The tumors in the LLC or MC38 tumor-bearing mice of the control group (n=5), TPE-IQ-2O PDT group (n=5), BMS202 group (n=5) and combined treatment (PDT combined with BMS202) group (n=5). (D, E) Tumor growth curves for LLC or MC38 tumor-bearing mice, *p < 0.05,***p < 0.001 vs. control group following the Dunnett test, ###p < 0.001 for pairwise comparison on day 16 following LSD test).