Research Paper Volume 13, Issue 1 pp 1383—1409

The therapeutic significance of the novel photodynamic material TPE-IQ-2O in tumors

Flow cytometry showed that TPE-IQ-2O PDT combined with a PD-L1 ICI increased the infiltration of CD8+ T cells into tumors. (A) Flow cytometric analysis of a CD8+ T lymphocyte-related phenotype in each group of mice bearing a subcutaneous LLC tumor. (B) Flow cytometric analysis of the CD8+ T lymphocyte-related phenotype in each group of mice bearing a subcutaneous MC38 tumor (*p

Figure 8. Flow cytometry showed that TPE-IQ-2O PDT combined with a PD-L1 ICI increased the infiltration of CD8+ T cells into tumors. (A) Flow cytometric analysis of a CD8+ T lymphocyte-related phenotype in each group of mice bearing a subcutaneous LLC tumor. (B) Flow cytometric analysis of the CD8+ T lymphocyte-related phenotype in each group of mice bearing a subcutaneous MC38 tumor (*p < 0.05, **p < 0.01, ***and ###p < 0.001 for pairwise comparison following Dunnett’s T3 post hoc test, ### p < 0.001 compared with any other group).