Research Paper Volume 13, Issue 3 pp 3909—3925

Dysregulation of USP18/FTO/PYCR1 signaling network promotes bladder cancer development and progression

PYCR1 promotes FTO-deficient xenograft tumor growth. (A) Tumor growth curves as recorded by measuring tumor volume. (B) Xenograft tumor morphology. (C) qPCR determining FTO and PYCR1 expression in xenograft tumor. (D) Ki67 immunohistochemistry on xenograft tumor sections. NC, negative control. OE, overexpression.

Figure 8. PYCR1 promotes FTO-deficient xenograft tumor growth. (A) Tumor growth curves as recorded by measuring tumor volume. (B) Xenograft tumor morphology. (C) qPCR determining FTO and PYCR1 expression in xenograft tumor. (D) Ki67 immunohistochemistry on xenograft tumor sections. NC, negative control. OE, overexpression.