Research Paper Volume 13, Issue 3 pp 3945—3956

MicroRNA-205-5p targets the HOXD9-Snail1 axis to inhibit triple negative breast cancer cell proliferation and chemoresistance

miR-205 inhibits breast cancer cell proliferation. (A) qRT-PCR was used to investigate knockdown efficiency and over-expression efficiency. (B) qRT-PCR was used to identify the effects of miR-205 knockdown treatment in BT-549 cells and miR-205 overexpression treatment in MDA-MB-231 cells. (C) miR-205 overexpression in MDA-MB-231 cells significantly promoted cell proliferation. (D) miR-205 knockdown in BT-549 cells significantly inhibited cell proliferation. (E) edu experiment was employed to study the cell proliferation of miR-205 knockdown treatment in BT-549 cells and miR-205 overexpression treatment in MDA-MB-231 cells. *P

Figure 2. miR-205 inhibits breast cancer cell proliferation. (A) qRT-PCR was used to investigate knockdown efficiency and over-expression efficiency. (B) qRT-PCR was used to identify the effects of miR-205 knockdown treatment in BT-549 cells and miR-205 overexpression treatment in MDA-MB-231 cells. (C) miR-205 overexpression in MDA-MB-231 cells significantly promoted cell proliferation. (D) miR-205 knockdown in BT-549 cells significantly inhibited cell proliferation. (E) edu experiment was employed to study the cell proliferation of miR-205 knockdown treatment in BT-549 cells and miR-205 overexpression treatment in MDA-MB-231 cells. *P<0.05, **P<0.01,***P<0.001.