Research Paper Volume 13, Issue 3 pp 4157—4181

CCDC167 as a potential therapeutic target and regulator of cell cycle-related networks in breast cancer

Networks from coiled-coil domain-containing protein 167 (CCDC167)-co-expressed genes in breast cancer. The Venn diagram circles represent co-expressed genes of CCDC167 from each database; the blue circle represents co-expressed genes in TCGA database, and the orange circle represents co-expressed genes in the METABRIC database. The MetaCore signaling pathway analysis demonstrated that the “cell cycle role of anaphase-promoting complex (APC) in cell cycle regulation” and cell cycle-related signaling (red rectangles) were significantly correlated with CCDC167 gene expression. Immune-response signaling is marked with blue rectangles, and ubiquinone metabolism is scored with red arrowheads.

Figure 2. Networks from coiled-coil domain-containing protein 167 (CCDC167)-co-expressed genes in breast cancer. The Venn diagram circles represent co-expressed genes of CCDC167 from each database; the blue circle represents co-expressed genes in TCGA database, and the orange circle represents co-expressed genes in the METABRIC database. The MetaCore signaling pathway analysis demonstrated that the “cell cycle role of anaphase-promoting complex (APC) in cell cycle regulation” and cell cycle-related signaling (red rectangles) were significantly correlated with CCDC167 gene expression. Immune-response signaling is marked with blue rectangles, and ubiquinone metabolism is scored with red arrowheads.