Research Paper Volume 13, Issue 3 pp 4258—4273

Cross-platform genomic identification and clinical validation of breast cancer diagnostic biomarkers

The exosomal transcriptome landscape of breast cancer. (A) The hsa-miR-423-5p expression level in breast cancer serum exosome is significantly elevated compared to those in serum from healthy female volunteers. (B) A total of 260 lncRNA and 110 mRNA transcripts are differentially expressed. (C) Top 10 GOs upregulated in breast cancer patients compared to controls. (D) Analysis of 20 enriched KEGG pathways between breast cancer patients and controls. (E) A total of 162 lncRNAs interact with 5 mRNAs (HLA-DPA1, HLA-DQA1, HLA-DRB1, HLA-DRB5, and KISS1R) between breast cancer patients and controls. (F) A total of 102 intersected genes of hsa-miR-423-5p predicted target mRNAs and differential expressed mRNAs in exosomes.

Figure 3. The exosomal transcriptome landscape of breast cancer. (A) The hsa-miR-423-5p expression level in breast cancer serum exosome is significantly elevated compared to those in serum from healthy female volunteers. (B) A total of 260 lncRNA and 110 mRNA transcripts are differentially expressed. (C) Top 10 GOs upregulated in breast cancer patients compared to controls. (D) Analysis of 20 enriched KEGG pathways between breast cancer patients and controls. (E) A total of 162 lncRNAs interact with 5 mRNAs (HLA-DPA1, HLA-DQA1, HLA-DRB1, HLA-DRB5, and KISS1R) between breast cancer patients and controls. (F) A total of 102 intersected genes of hsa-miR-423-5p predicted target mRNAs and differential expressed mRNAs in exosomes.