Research Paper Volume 13, Issue 1 pp 1458—1472

CHIP protects against MPP+/MPTP-induced damage by regulating Drp1 in two models of Parkinson’s disease

CHIP improved cell damage caused by MPP+ and modulated Bcl-2/Bax Ratio. (A–C) Overexpression of CHIP before MPP+ induced increased cell viability, decreased LDH level and increased ATP level. Decreased CHIP played the opposite role. (D, E) The increased Bcl-2/Bax ratio caused by MPP+ was inhibited in CHIP-overexpression group, while in sh-CHIP group, the ratio was even higher. *P

Figure 2. CHIP improved cell damage caused by MPP+ and modulated Bcl-2/Bax Ratio. (AC) Overexpression of CHIP before MPP+ induced increased cell viability, decreased LDH level and increased ATP level. Decreased CHIP played the opposite role. (D, E) The increased Bcl-2/Bax ratio caused by MPP+ was inhibited in CHIP-overexpression group, while in sh-CHIP group, the ratio was even higher. *P<0.05.