Research Paper Volume 13, Issue 1 pp 1458—1472

CHIP protects against MPP+/MPTP-induced damage by regulating Drp1 in two models of Parkinson’s disease

Overexpression of CHIP in AAV-mediated transduction mice and NES-CHIP mice. (A, C) Immunofluorescence for CHIP (red), GFP (green) and nucleus (blue) showed that CHIP overexpressed in mice injected with AAV/BBB-CHIP-GFP. (B, D) In NES-CHIP mice, immunofluorescence proved a higher level of CHIP (red) than that in wild-type littermates. (E–H) Western blotting showed increased CHIP level in SNpc and striatum of mice received AAV/BBB-CHIP-GFP injection and NES-CHIP. CHIP *P

Figure 6. Overexpression of CHIP in AAV-mediated transduction mice and NES-CHIP mice. (A, C) Immunofluorescence for CHIP (red), GFP (green) and nucleus (blue) showed that CHIP overexpressed in mice injected with AAV/BBB-CHIP-GFP. (B, D) In NES-CHIP mice, immunofluorescence proved a higher level of CHIP (red) than that in wild-type littermates. (EH) Western blotting showed increased CHIP level in SNpc and striatum of mice received AAV/BBB-CHIP-GFP injection and NES-CHIP. CHIP *P<0.05.