Research Paper Volume 13, Issue 1 pp 1458—1472

CHIP protects against MPP+/MPTP-induced damage by regulating Drp1 in two models of Parkinson’s disease

CHIP overexpression ameliorated MPTP-induced motor impairments in mice. Pole test, rotarod test and open field test were performed to evaluate motor function of each group. (A, D) Total time the mice used to climb from top of the pole. (B, E) Latency to fall in rotarod test after MPTP administration. (C, F) Number of grids the mice crossed in 5 minutes in the open field test. *P

Figure 7. CHIP overexpression ameliorated MPTP-induced motor impairments in mice. Pole test, rotarod test and open field test were performed to evaluate motor function of each group. (A, D) Total time the mice used to climb from top of the pole. (B, E) Latency to fall in rotarod test after MPTP administration. (C, F) Number of grids the mice crossed in 5 minutes in the open field test. *P<0.05.