Research Paper Volume 13, Issue 1 pp 1458—1472

CHIP protects against MPP+/MPTP-induced damage by regulating Drp1 in two models of Parkinson’s disease

Western blotting of proteins about mitochondrial fusion and fission in SNpc and striatum in mice treated with AAV/BBB-CHIP-GFP or AAV/BBB-GFP followed by MPTP administration. Statistical analysis showed that CHIP increased in AAV/BBB-CHIP-GFP injected mice. (A) Drp1 was upregulated after MPTP administration. CHIP overexpression inhibited the rising trend of Drp1. (B–F) Quantitative analysis of the blots. *P

Figure 9. Western blotting of proteins about mitochondrial fusion and fission in SNpc and striatum in mice treated with AAV/BBB-CHIP-GFP or AAV/BBB-GFP followed by MPTP administration. Statistical analysis showed that CHIP increased in AAV/BBB-CHIP-GFP injected mice. (A) Drp1 was upregulated after MPTP administration. CHIP overexpression inhibited the rising trend of Drp1. (BF) Quantitative analysis of the blots. *P<0.05.