Research Paper Volume 13, Issue 1 pp 1458—1472
CHIP protects against MPP+/MPTP-induced damage by regulating Drp1 in two models of Parkinson’s disease
Figure 9. Western blotting of proteins about mitochondrial fusion and fission in SNpc and striatum in mice treated with AAV/BBB-CHIP-GFP or AAV/BBB-GFP followed by MPTP administration. Statistical analysis showed that CHIP increased in AAV/BBB-CHIP-GFP injected mice. (A) Drp1 was upregulated after MPTP administration. CHIP overexpression inhibited the rising trend of Drp1. (B–F) Quantitative analysis of the blots. *P<0.05.