Research Paper Volume 12, Issue 24 pp 26199—26220

Ring finger protein 2 promotes colorectal cancer progression by suppressing early growth response 1

Figure 1. RNF2 expression was upregulated in CRC tumor tissues and was associated with patients’ prognoses. (A) Representative immunohistochemistry results depicting positive and negative RNF2 staining in clinical CRC tumor tissues and adjacent normal tissues. The pictures on the right are the magnified view of the yellow boxes on the left. Scale bar: 200 μm. (B) H-scores for RNF2 expression in 313 CRC tumor tissues and adjacent normal tissues. ***p<0.001 versus adjacent normal tissue. (C) Overall survival of RNF2-positive or -negative CRC patients. (D) Local relapse-free survival of RNF2-positive or -negative CRC patients. (E) Distant metastasis-free survival of RNF2-positive or -negative CRC patients.