Research Paper Volume 13, Issue 3 pp 4357—4369

The hepatic microenvironment promotes lung adenocarcinoma cell proliferation, metastasis, and epithelial–mesenchymal transition via METTL3-mediated N6-methyladenosine modification of YAP1

YAP1 inhibition suppressed the ability of the hepatic inflammatory microenvironment to promote EMT. (A) Changes in the expression of the EMT indexes E-cadherin and vimentin in A549 and H1975 cells were detected by confocal laser scanning microscopy (×630). (B) Changes in CDH1 and VIM mRNA expression in A549 and H1975 cells were detected by real-time PCR (*P

Figure 6. YAP1 inhibition suppressed the ability of the hepatic inflammatory microenvironment to promote EMT. (A) Changes in the expression of the EMT indexes E-cadherin and vimentin in A549 and H1975 cells were detected by confocal laser scanning microscopy (×630). (B) Changes in CDH1 and VIM mRNA expression in A549 and H1975 cells were detected by real-time PCR (*P<0.05 versus the control group).