Research Paper Volume 13, Issue 3 pp 4482—4502

Identification of downstream signaling cascades of ACK1 and prognostic classifiers in non-small cell lung cancer

Inhibitory efficiency of ACK1 inhibitor alone or in combination with MK-2206/selumetinib on NSCLC cell lines. Proliferation assay of the A549 cell line (A), H358 cell line (B), and H23 cell line (C) treated with drugs as indicated. Combined therapy performed significantly better than single agents in suppressing cell survival. * and ** denoted PP

Figure 2. Inhibitory efficiency of ACK1 inhibitor alone or in combination with MK-2206/selumetinib on NSCLC cell lines. Proliferation assay of the A549 cell line (A), H358 cell line (B), and H23 cell line (C) treated with drugs as indicated. Combined therapy performed significantly better than single agents in suppressing cell survival. * and ** denoted P<0.05 and P<0.01, respectively. Data are represented as the mean ± SD.