Research Paper Volume 13, Issue 5 pp 6592—6605

Lupeol ameliorates LPS/D-GalN induced acute hepatic damage by suppressing inflammation and oxidative stress through TGFβ1-Nrf2 signal pathway

Lupeol alleviates LPS/GalN-induced liver injury in mice. (A) Diagrammatic sketch mice modeling and lupeol administration. (B, C) Changes in serum ALT and AST. (D) H&E staining was used to detect the liver histopathological changes. (E, F) Expression of caspase 9 and cleaved-caspase 9 protein in mice. (G) TUNEL staining of paraffin liver sections in control mice and mice treated with LPS/GalN or lupeol. Data are expressed as the mean ± SEM, n=3-6 per group, *P

Figure 2. Lupeol alleviates LPS/GalN-induced liver injury in mice. (A) Diagrammatic sketch mice modeling and lupeol administration. (B, C) Changes in serum ALT and AST. (D) H&E staining was used to detect the liver histopathological changes. (E, F) Expression of caspase 9 and cleaved-caspase 9 protein in mice. (G) TUNEL staining of paraffin liver sections in control mice and mice treated with LPS/GalN or lupeol. Data are expressed as the mean ± SEM, n=3-6 per group, *P<0.05, **P<0.01, ***P<0.001, control group vs other groups. #P<0.05, ##P<0.01, ### P<0.001. Figures are magnified as 200x, bar=50μm.