Research Paper Volume 13, Issue 5 pp 6592—6605

Lupeol ameliorates LPS/D-GalN induced acute hepatic damage by suppressing inflammation and oxidative stress through TGFβ1-Nrf2 signal pathway

Lupeol downregulates TGFβr1 and upregulates Nrf2 pathway in mice with ALI. (A, B) Immunohistochemistry staining and quantitative analysis of TGFβ1. (C) Western blot analysis for the expressions of TGFβr1. (D) Quantitative analysis of TGFβr1 protein. (E, F) Immunohistochemistry analysis and quantification for detecting the expressions of TGFβr1. (G, H) Western blots and quantitative results for Nrf2. All data are shown as the mean ± SEM, n=3-4 group, *P

Figure 5. Lupeol downregulates TGFβr1 and upregulates Nrf2 pathway in mice with ALI. (A, B) Immunohistochemistry staining and quantitative analysis of TGFβ1. (C) Western blot analysis for the expressions of TGFβr1. (D) Quantitative analysis of TGFβr1 protein. (E, F) Immunohistochemistry analysis and quantification for detecting the expressions of TGFβr1. (G, H) Western blots and quantitative results for Nrf2. All data are shown as the mean ± SEM, n=3-4 group, *P<0.05 vs control group, #P<0.05 vs model group. Figures are magnified as 200x, bar=50μm.