Research Paper Volume 13, Issue 4 pp 5020—5033

Toxic effect of titanium dioxide nanoparticles on corneas in vitro and in vivo

Oxidative damage of TiO2 NPs to corneal endothelial cells. (A) Intracellular ROS of corneal endothelial cells with indicated treatment, bar = 40 μm. Detection of MDA content (B), SOD activity (C) and GSH-Px activity (D) in primary corneal endothelial cells with indicated treatment. **P***P#P##P&P&&P%P%%P2O2 group, @P@@P2O2 group.

Figure 2. Oxidative damage of TiO2 NPs to corneal endothelial cells. (A) Intracellular ROS of corneal endothelial cells with indicated treatment, bar = 40 μm. Detection of MDA content (B), SOD activity (C) and GSH-Px activity (D) in primary corneal endothelial cells with indicated treatment. **P<0.01 vs. control group, ***P<0.001 vs. control group, #P<0.05 vs. 25 μg/mL group, ##P<0.01 vs. 25 μg/mL group, &P<0.05 vs. 50 μg/mL group, &&P<0.01 vs. 50 μg/mL group, %P<0.05 vs. 100 μg/mL group, %%P<0.01 vs. H2O2 group, @P<0.05 vs. 50 μg/mL group, @@P<0.01 vs. H2O2 group.