Research Paper Volume 13, Issue 4 pp 5020—5033

Toxic effect of titanium dioxide nanoparticles on corneas in vitro and in vivo

Regulation of functional proteins by TiO2 NPs in corneal endothelial cells. Immunofluorescence analysis of the expression of ZO-1 (A), Na-K-ATPase (B) and β-catenin (C) in primary corneal endothelial cells with TiO2 NPs treatment, H2O2 treatment or Nrf2 overexpression. bar = 20 μm. *P

Figure 5. Regulation of functional proteins by TiO2 NPs in corneal endothelial cells. Immunofluorescence analysis of the expression of ZO-1 (A), Na-K-ATPase (B) and β-catenin (C) in primary corneal endothelial cells with TiO2 NPs treatment, H2O2 treatment or Nrf2 overexpression. bar = 20 μm. *P<0.05, **P<0.01, ***P<0.001.